STING activator Compound 53 ( 1-(2-chloro-6-fluorobenzyl)-3,3-dimethyl-2-oxo-N-(2,4,6-trifluorobenzyl)indoline-6-carboxamide )

产品货号. M28935 CAS No. 2259624-71-8

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HNMR

HPLC

MSDS

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产品名称

STING activator Compound 53
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

基于羟吲哚核心结构的 STING 激活剂化合物 53 在永生化和原代细胞中表现出强大的 STING（人 EC50 185 nM）功能激活，并且细胞因子诱导指纹与 STING 激活一致。
产品描述

STING activator Compound 53 based on an oxindole core structure demonstrated robust on-target functional activation of STING (human EC50 185 nM) in immortalised and primary cells and a cytokine induction fingerprint consistent with STING activation.
体外实验

STING agonist-12 (Compound 53) (10 μM) shows excellent pan-polymorph activity across the panel of STING proteins (92%, 107% and 92% against R232, H232 and HAQ, respectively) in HEK293T cells.STING agonist-12 is not active at mouse STING.
体内实验

STING agonist-12 (Compound 53) (5 mpk for i.v.; 10 mpk for p.o.) is well-absorbed with a short terminal half-life. Animal Model:Balb/c mice (n=3) Dosage:5 or 10 mpk Administration:Lateral tail vein or oral gavage (Pharmacokinetic Analysis)Result:Pharmacokinetic profile of STING agonist-12 (Compound 53) in mouse.
同义词

1-(2-chloro-6-fluorobenzyl)-3,3-dimethyl-2-oxo-N-(2,4,6-trifluorobenzyl)indoline-6-carboxamide
通路

Immunology/Inflammation
靶点

STING
受体

Autophagy
研究领域

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适应症

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1.Gao Y, et al. Golgi-associated LC3 lipidation requires V-ATPase in noncanonical autophagy. Cell Death Dis. 2016 Aug 11;7(8):e2330.

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