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STING activator Compound 53
CAS No. 2259624-71-8
STING activator Compound 53 ( 1-(2-chloro-6-fluorobenzyl)-3,3-dimethyl-2-oxo-N-(2,4,6-trifluorobenzyl)indoline-6-carboxamide )
产品货号. M28935 CAS No. 2259624-71-8
基于羟吲哚核心结构的 STING 激活剂化合物 53 在永生化和原代细胞中表现出强大的 STING（人 EC50 185 nM）功能激活，并且细胞因子诱导指纹与 STING 激活一致。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 5MG | ￥648 | 有现货 |
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| 10MG | ￥1021 | 有现货 |
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| 25MG | ￥2130 | 有现货 |
|
| 50MG | ￥3418 | 有现货 |
|
| 100MG | ￥5087 | 有现货 |
|
| 500MG | ￥10935 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称STING activator Compound 53
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述基于羟吲哚核心结构的 STING 激活剂化合物 53 在永生化和原代细胞中表现出强大的 STING（人 EC50 185 nM）功能激活，并且细胞因子诱导指纹与 STING 激活一致。
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产品描述STING activator Compound 53 based on an oxindole core structure demonstrated robust on-target functional activation of STING (human EC50 185 nM) in immortalised and primary cells and a cytokine induction fingerprint consistent with STING activation.
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体外实验STING agonist-12 (Compound 53) (10 μM) shows excellent pan-polymorph activity across the panel of STING proteins (92%, 107% and 92% against R232, H232 and HAQ, respectively) in HEK293T cells.STING agonist-12 is not active at mouse STING.
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体内实验STING agonist-12 (Compound 53) (5 mpk for i.v.; 10 mpk for p.o.) is well-absorbed with a short terminal half-life. Animal Model:Balb/c mice (n=3) Dosage:5 or 10 mpk Administration:Lateral tail vein or oral gavage (Pharmacokinetic Analysis)Result:Pharmacokinetic profile of STING agonist-12 (Compound 53) in mouse.
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同义词1-(2-chloro-6-fluorobenzyl)-3,3-dimethyl-2-oxo-N-(2,4,6-trifluorobenzyl)indoline-6-carboxamide
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通路Immunology/Inflammation
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靶点STING
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受体Autophagy
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研究领域——
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适应症——
化学信息
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CAS Number2259624-71-8
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分子量490.88
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分子式C25H19ClF4N2O2
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纯度>98% (HPLC)
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溶解度In Vitro:?DMSO : 250 mg/mL (509.29 mM)
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SMILESCC(C)(c(ccc(C(NCc(c(F)cc(F)c1)c1F)=O)c1)c1N1Cc(c(F)ccc2)c2Cl)C1=O
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化学全称——
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1.Gao Y, et al. Golgi-associated LC3 lipidation requires V-ATPase in noncanonical autophagy. Cell Death Dis. 2016 Aug 11;7(8):e2330.
